Table 2 Nanomaterial-based delivery of oncolytic adenovirus. Nanomaterials with different attribute (cationic nanomaterials, hydrogels, and magnetic nanoparticles) can improve the local delivery efficiency of virus to tumor tissues. Table summarizes individual cases discussed in this review
From: Overcoming the limitations of locally administered oncolytic virotherapy
No. | Nanomaterial | Characteristics of nanomaterial | Oncolytic adenovirus | Therapeutic transgene | Complexation Method | Reference |
|---|---|---|---|---|---|---|
1 | deoxycholic acid-conjugated PEI (DA3) | Cationic nanomaterial | RdB-KOX | Artificial transcriptional repressor zinc-finger protein specific to vascular endothelial growth factor (VEGF) promoter | Electrostatic interaction | [27] |
2 | mPEG-PEI-g-Arg-S-S-Arg-g-PEI-mPEG (PPSA) | Cationic/bioreducible nanomaterial | DWP418 | Human relaxin | Electrostatic interaction | [24] |
3 | multidegradable bioreducible core-cross-linked PEI (rPEI) | Cationic/bioreducible nanomaterial | RdB/shMet | Short hairpin RNA specific to c-Met | Electrostatic interaction | [29] |
4 | PEGylated paclitaxel conjugated to arginine grafted bioreducible polymer (APP) | Cationic, bioreducible, and chemodrug-conjugated nanomaterial | oAd-vp53 | p53 variant that is resistant to p53 inactivation | Electrostatic interaction | [32] |
5 | lithium 3-[2-(perfluoroalkyl)ethylthio]propionate) & 25 kDa branched PEI (PEI-Mag2) | Cationic/magnetic nanomaterial | dl520 | No therapeutic transgene | Electrostatic interaction | [33] |
6 | polybrene-modified nanoparticles (PB-Mag1) & silica-modified nanoparticle decorated with branched PEI (SO-Mag2) | Cationic/magnetic nanomaterial | dl520 | No therapeutic transgene | Electrostatic interaction | [34] |
7 | PEGylated and cross-linked iron oxide nanoparticles (PCION) | Cationic/magnetic nanomaterial | HmT | No therapeutic transgene | Electrostatic interaction | [35] |
8 | Injectable alginate gel | Biodegradable gel | DWP418 | Human relaxin | Gel encapsulation | [36] |
9 | silk-elastin like protein polymer hydrogel (SELP hydrogel) | Biodegradable gel | Ad-C-Met | Short hairpin RNA specific to c-Met | Gel encapsulation | [37] |
10 | in situ cross-linkable gelatin hydrogels using gelatin-hydroxyphenyl propionic acid (GHPA gel) | Biodegradable gel | oAd-TRAIL | Secretable trimeric tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) | Gel encapsulation | [38] |
11 | in situ cross-linkable gelatin hydrogels using gelatin-hydroxyphenyl propionic acid (GHPA gel) | Biodegradable gel | RdB/IL-12/GMCSF | Interleukin (IL)-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF) | Gel encapsulation | [44] |
12 | gold nanorod (GNR) | Laser-induced hyperthermia | RdB-K35/KOX | Artificial transcriptional repressor zinc-finger protein specific to VEGF promoter | No complexation | [50] |