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Table 2 Frequently used human NB cells lines for preclinical testing

From: Developing preclinical models of neuroblastoma: driving therapeutic testing

Cell LineMYCN StatusALK MutationP53 mutationPreclinical Testing References
KELLYAmplifiedWTWT[69,70,71,72,73,74,75]
CHP-212AmplifiedWTWT[76, 77]
SKNASNon-AmplifiedWTH168R[76, 78,79,80,81,82,83,84,85,86]
SH-SY-5YNon-AmplifiedF1174 LWT[70, 71, 75, 78, 87,88,89]
IMR-32AmplifiedWTWT[80, 88, 90, 91]
IMR-05AmplifiedWTWT[37, 86, 89, 92]
LA-N-5AmplifiedR1275QWT[71, 93, 94]
NB-1AmplifiedWT; AmplifiedWT[95, 96]
SK-N-BE(2)AmplifiedWTC135F[75, 78, 83, 89, 86, 97]
SK-N-BE(2)-CAmplifiedWTC135F[78]
CHP-134AmplifiedWTWT[78, 89, 98, 99]
SK-N-DZAmplifiedWTR110L[82, 84, 85]
NB-1691AmplifiedWTWT[83, 100, 101]