Developing preclinical models of neuroblastoma: driving therapeutic testing

Table 2 Frequently used human NB cells lines for preclinical testing

Cell Line	MYCN Status	ALK Mutation	P53 mutation	Preclinical Testing References
KELLY	Amplified	WT	WT	[69,70,71,72,73,74,75]
CHP-212	Amplified	WT	WT	[76, 77]
SKNAS	Non-Amplified	WT	H168R	[76, 78,79,80,81,82,83,84,85,86]
SH-SY-5Y	Non-Amplified	F1174 L	WT	[70, 71, 75, 78, 87,88,89]
IMR-32	Amplified	WT	WT	[80, 88, 90, 91]
IMR-05	Amplified	WT	WT	[37, 86, 89, 92]
LA-N-5	Amplified	R1275Q	WT	[71, 93, 94]
NB-1	Amplified	WT; Amplified	WT	[95, 96]
SK-N-BE(2)	Amplified	WT	C135F	[75, 78, 83, 89, 86, 97]
SK-N-BE(2)-C	Amplified	WT	C135F	[78]
CHP-134	Amplified	WT	WT	[78, 89, 98, 99]
SK-N-DZ	Amplified	WT	R110L	[82, 84, 85]
NB-1691	Amplified	WT	WT	[83, 100, 101]

ISSN: 2524-4426