Table 2 2D and 3D in vitro models for studying obesogens. Note:Â -- under Matrix indicates a 2D cell culture study
From: Mechanisms of action, chemical characteristics, and model systems of obesogens
Matrix | Cell Type | Obesogen | Source |
|---|---|---|---|
– | 3T3-L1 (murine preadipocyes) | Tributyltin (TBT) | |
Bisphenol A (BPA) | |||
Bisphenol S (BPS) | [102] | ||
Bisphenol A diglycidyl ether (BADGE) | [100] | ||
Triphenyltin | [95] | ||
Dioctyl sodium sulfosuccinate (DOSS) | [52] | ||
Geneistein & naringenin | [103] | ||
Phthalate monoesters | [32] | ||
4-nonylphenol (NP) | [101] | ||
Mono-ethylhexyl phthalate (MEHP) | [50] | ||
Flavanone | [104] | ||
Bixin, norbixin | [105] | ||
Emodin | [106] | ||
C2C12 (murine) | Mono-ethylhexyl phthalate (MEHP) | [50] | |
HELA (human) | Mono-ethylhexyl phthalate (MEHP) | [50] | |
Human embryonic kidney cells (HEK293C) | Dioctyl sodium sulfosuccinate (DOSS) | [52] | |
HepG2 (human liver carcinoma cells) | Bisphenol A (BPA), Bisphenol S (BPS) | [102] | |
Human adipose-derived stem cells (hASCs) | Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) | [102] | |
Tributyltin (TBT) | [44] | ||
Murine adipose derived stem cells (mASCs) | Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) | [102] | |
Tributyltin (TBT) | [44] | ||
Fao (murine hepatoma cells) | Phthalate monoesters | [32] | |
COS (monkey kidney-derived cells) | Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) | [102] | |
MBzP, MBuP | [50] | ||
Mono-ethylhexyl phthalate (MEHP) | |||
THP-1 macrophages (human) | Psi-baptigenin, hesperidin | [108] | |
TARM-Luc (human, transfected T47-D epithelial cells) | Monosodium glutamate (MSG) | [109] | |
KS483 (murine calvaria) | Soy phytoestrogen genistein | [110] | |
C57BL/6 (murine–derived bone marrow stromal cells) | Firemaster 550 | [51] | |
collagen embedded silk scaffolds | Human embryonic-derived stem cells (hESCs) | Tributyltin (TBT), Bisphenol A (BPA), Bisphenol S (BPS) | [111] |
silk scaffolds | Human adipose-derived stem cells (hASCs), Human umbilical vein endothelial cells (HUVECs) | – | [112] |
silk fibroin matrices | Human adipose-derived stem cells (hASCs) | – | [113] |
collagen type 1 | OP9 (murine mesenchymal stromal pluripotent cells), HaCaT (human keratinocytes) | Super Hatomugi (SPH) | [114] |
bacterial nanocellulose | Murine mesenchymal stem cells (mMSCs) | – | [115] |
fibrous polyethylene teraphthalate scaffolds | 3T3-L1 (murine preadipocyes) | – | [116] |
low-shear rotary bioreactor | Murine adipose-derived stem cells (mASCs) | – | [117] |
polyglycolic acid fiber meshes | 3T3-L1 (murine preadipocyes) | – | [118] |
adipospheres created via magnetic nanoparticle levitation system | 3T3-L1 (murine preadipocyes) | – | [119] |