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Table 2 2D and 3D in vitro models for studying obesogens. Note: -- under Matrix indicates a 2D cell culture study

From: Mechanisms of action, chemical characteristics, and model systems of obesogens

Matrix Cell Type Obesogen Source
3T3-L1 (murine preadipocyes) Tributyltin (TBT) [42, 43, 94,95,96,97,98,99]
Bisphenol A (BPA) [97,98,99]
Bisphenol S (BPS) [102]
Bisphenol A diglycidyl ether (BADGE) [100]
Triphenyltin [95]
Dioctyl sodium sulfosuccinate (DOSS) [52]
Geneistein & naringenin [103]
Phthalate monoesters [32]
4-nonylphenol (NP) [101]
Mono-ethylhexyl phthalate (MEHP) [50]
Flavanone [104]
Bixin, norbixin [105]
Emodin [106]
C2C12 (murine) Mono-ethylhexyl phthalate (MEHP) [50]
HELA (human) Mono-ethylhexyl phthalate (MEHP) [50]
Human embryonic kidney cells (HEK293C) Dioctyl sodium sulfosuccinate (DOSS) [52]
HepG2 (human liver carcinoma cells) Bisphenol A (BPA), Bisphenol S (BPS) [102]
Human adipose-derived stem cells (hASCs) Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) [102]
Tributyltin (TBT) [44]
Murine adipose derived stem cells (mASCs) Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) [102]
Tributyltin (TBT) [44]
Fao (murine hepatoma cells) Phthalate monoesters [32]
COS (monkey kidney-derived cells) Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) [102]
MBzP, MBuP [50]
Mono-ethylhexyl phthalate (MEHP) [50, 107]
THP-1 macrophages (human) Psi-baptigenin, hesperidin [108]
TARM-Luc (human, transfected T47-D epithelial cells) Monosodium glutamate (MSG) [109]
KS483 (murine calvaria) Soy phytoestrogen genistein [110]
C57BL/6 (murine–derived bone marrow stromal cells) Firemaster 550 [51]
collagen embedded silk scaffolds Human embryonic-derived stem cells (hESCs) Tributyltin (TBT), Bisphenol A (BPA), Bisphenol S (BPS) [111]
silk scaffolds Human adipose-derived stem cells (hASCs), Human umbilical vein endothelial cells (HUVECs) [112]
silk fibroin matrices Human adipose-derived stem cells (hASCs) [113]
collagen type 1 OP9 (murine mesenchymal stromal pluripotent cells), HaCaT (human keratinocytes) Super Hatomugi (SPH) [114]
bacterial nanocellulose Murine mesenchymal stem cells (mMSCs) [115]
fibrous polyethylene teraphthalate scaffolds 3T3-L1 (murine preadipocyes) [116]
low-shear rotary bioreactor Murine adipose-derived stem cells (mASCs) [117]
polyglycolic acid fiber meshes 3T3-L1 (murine preadipocyes) [118]
adipospheres created via magnetic nanoparticle levitation system 3T3-L1 (murine preadipocyes) [119]