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Table 1 Nominal predictors, their categories, and labels with the frequencies of unique values (Frequency presents the percentage of the related label in a total observation of 407)

From: Prediction of the synergistic effect of antimicrobial peptides and antimicrobial agents via supervised machine learning

Category

Variables

Labels (Frequency (%))

Antimicrobial Agent Characteristics

Antimicrobial Agent Name

Amikacin (2.7), Amoxicillin (1.2), Amphotericin B (1.0), Ampicillin (2.5), Azithromycin (2.5), Bacitracin (0.2), Cefepime (1.0), Cefotaxime (0.7), Ceftazidime (2.7), Ceftriaxone (1.0), Cephalothin (0.7), Chloramphenicol (3.2), Ciprofloxacin (7.6), Clarithromycin (1.5), Clindamycin (1.2), Colistin (0.7), Doripenem (1.0), Doxycycline (0.7), Erythromycin (7.1), Fluconazole (1.2), Gentamicin (9.8), Imipenem (4.2), Kanamycin (1.7), Levofloxacin (0.5), Meropenem (3.2), Minocycline (0.7), Novobiocin (1.0), Ofloxacin (1.0), Oxacillin (1.7), Penicillin (0.5), Piperacillin (1.5), Polymyxin B (8.1), Rifampicin (10.6), Streptomycin (0.7), Tetracycline (2.9), Tobramycin (1.5), Vancomycin (9.8)

Antimicrobial Agent Class

Aminocoumarin (1.0), Aminoglycoside (16.5), Ansamycin (10.6), Azole (1.2), Beta-lactam (21.9), Chloramphenicol (3.2), Fluoroquinolone (9.1), Glycopeptide (9.8), Lincosamide (1.2), Macrolide (12.0), Polymyxin (8.8), Polypeptide (0.2), Tetracycline (4.4)

Mechanism of Action

Antimetabolite (2.0), Cell membrane (11.1), Cell membrane and Nucleic acid (11.3), Cell membrane and Protein (0.7), Cell wall (25.8), Cell wall and Protein (0.7), Nucleic acid (25.1), Nucleic acid and Antimetabolite (0.5), Protein (22.9)

Gram Activity

Gram-negative (11.3), Gram-positive (14.0), Gram-positive and Gram-negative (74.7)

Microbial Characteristics

Microbial Species

A. baumannii (7.9), C. albicans (1.2), C. auris (0.5), C. neoformans (0.5), E. faecalis (0.7), E. coli (23.3), K. aerogenes (0.5), K. pneumoniae (11.5), M. luteus (0.7), M. bovis (0.2), M. smegmatis (0.7), M. tuberculosis (0.2), P. aeruginosa (32.2), S. aureus (15.0), S. epidermidis (4.2), S. pyogenes (0.5)

Microorganism or Gram Class

Fungus (0.5), Gram-negative (75.4), Gram-positive (23.6), Gram-positive and Gram-negative (0.5)