Therapy resistant ulcers are wounds that remain open for a long time period and often arise from chronic venous disease, prolonged pressure or diabetes. For healing of chronic wounds, revitalization of the ine...
Authors: Hanneke N. Monsuur, Ester M. Weijers, Susan Gibbs and Lenie J. van den Broek
Adenovirus (Ad) has been most extensively evaluated gene transfer vector in clinical trials due to facile production in high viral titer, highly efficient transduction, and proven safety record. Similarly, an ...
Excessive extracellular matrix (ECM) deposition is a hallmark feature in fibrosis and tissue remodelling diseases. Typically, mesenchymal cells will produce collagens under standard 2D cell culture conditions,...
Authors: Robert B. Good, Jessica D. Eley, Elaine Gower, Genevieve Butt, Andrew D. Blanchard, Andrew J. Fisher and Carmel B. Nanthakumar
Mesenchymal stromal cells (MSCs) are widely used in clinical trials for bone repair and regeneration. Despite previous evidence showing a prominent osteogenic potential of 2D cultured CD271 enriched MSCs, the ...
Authors: Sylvia Müller, Lyndsey Nicholson, Naif Al Harbi, Elena Mancuso, Elena Jones, Anne Dickinson, Xiao Nong Wang and Kenneth Dalgarno
Due to the presence of high noise level in tomographic series of energy filtered transmission electron microscopy (EFTEM) images, alignment and 3D reconstruction steps become so difficult. To improve the align...
Authors: Soumia Sid Ahmed, Zoubeida Messali, Larbi Boubchir, Ahmed Bouridane, Sergio Marco and Cédric Messaoudi
In this paper, we focus on robots used for laparoscopic surgery, which is one of the most active areas for research and development of surgical robots. We introduce research and development of laparoscope-hold...
Authors: Kenji Kawashima, Takahiro Kanno and Kotaro Tadano
Currently there are no standard models with which to evaluate the biomechanical performance of calcified tissue adhesives, in vivo. We present, herein, a pre-clinical murine distal femoral bone model for evaluati...
Authors: Philip Procter, Michael Pujari-Palmer, Gry Hulsart-Billström, David Wenner, Gerard Insley, Sune Larsson and Håkan Engqvist
Advancement in polymer technologies, facilitated predominantly through chemical engineering approaches or through the identification and utilization of novel renewable resources, has been a steady focus of bio...
Authors: Katarzyna Krukiewicz, Jorge Fernandez, Małgorzata Skorupa, Daria Więcławska, Anup Poudel, Jose-Ramon Sarasua, Leo R. Quinlan and Manus J. P. Biggs
In Photoacoustic imaging (PAI), the most prevalent beamforming algorithm is delay-and-sum (DAS) due to its simple implementation. However, it results in a low quality image affected by the high level of sidelo...
Authors: Moein Mozaffarzadeh, Bahador Makkiabadi, Maryam Basij and Mohammad Mehrmohammadi
Magnetic resonance imaging (MRI) is an inherently slow imaging modality, since it acquires multi-dimensional k-space data through 1-D free induction decay or echo signals. This often limits the use of MRI, esp...
Frailty assessment is a critical approach in assessing the health status of older people. The clinical tools deployed by geriatricians to assess frailty can be grouped into two categories; using a questionnair...
Authors: Yasmeen Naz Panhwar, Fazel Naghdy, Golshah Naghdy, David Stirling and Janette Potter
Long double-stranded RNAs (dsRNAs) are duplex RNAs that can induce immune response when present in mammalian cells. These RNAs are historically associated with viral replication, but recent evidence suggests t...
Authors: Ahsan Ausaf Ali, Minjeong Kang, Raisa Kharbash and Yoosik Kim
Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or...
Authors: Héctor Capella-Monsonís, Stephen Kearns, Jack Kelly and Dimitrios I. Zeugolis
Corneal endothelium (CE) images provide valuable clinical information regarding the health state of the cornea. Computation of the clinical morphometric parameters requires the segmentation of endothelial cell...
Authors: Juan P. Vigueras-Guillén, Busra Sari, Stanley F. Goes, Hans G. Lemij, Jeroen van Rooij, Koenraad A. Vermeer and Lucas J. van Vliet
In neurology and rehabilitation the primary interest for using wearables is to supplement traditional patient assessment and monitoring in hospital settings with continuous data collection at home and in commu...
Authors: Margit Alt Murphy, Filip Bergquist, Bengt Hagström, Niina Hernández, Dongni Johansson, Fredrik Ohlsson, Leif Sandsjö, Jan Wipenmyr and Kristina Malmgren
Surgery of the pancreas is a relatively new field, with operative series appearing only in the last 50 years. Surgery of the pancreas is technically challenging. The entire field of general surgery changed rad...
This editorial accompanies the launch of BMC Biomedical Engineering, a new open access, peer-reviewed journal within the BMC series, which seeks to publish articles on all aspects of biomedical engineering. As on...
Authors: Alexandros Houssein, Alan Kawarai Lefor, Antonio Veloso, Zhi Yang, Jong Chul Ye, Dimitrios I. Zeugolis and Sang Yup Lee
