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Table 3 Average performance metrics of the 3-repeated 5-fold cross-validation strategy for different classifiers (ACC, F1, REC, and PRE values are given as percentages (%) and the ET unit is s.)

From: Prediction of the synergistic effect of antimicrobial peptides and antimicrobial agents via supervised machine learning

Classifier

Train

Validation

ACC

AUC

ACC

AUC

F1

REC

PRE

ET

p-value

LR

77.60

0.85

66.60

0.71

66.20

66.55

67.40

0.76

.803

LDA

80.25

0.88

68.25

0.73

68.00

68.25

69.20

1.56

.544

GPC

99.00

1.00

73.95

0.80

73.75

73.90

74.75

3.68

\(<.005\)

XGBC

100.00

1.00

72.80

0.81

72.40

72.85

74.10

3.95

.017

LGBMC

99.75

1.00

75.75

0.82

75.30

75.65

77.40

1.68

\(<.005\)

KNN

81.95

0.90

72.85

0.77

72.50

72.75

74.05

1.05

.017

DTC

100.00

1.00

70.45

0.70

70.25

70.45

70.95

0.69

.237

ETC

100.00

1.00

63.80

0.64

63.40

63.80

64.55

0.66

.972

GNB

70.20

0.81

61.80

0.71

60.75

61.85

62.75

0.69

\(>.999\)

BNB

71.45

0.77

65.90

0.70

65.15

65.80

66.35

0.70

.868

SVM

74.65

0.81

68.85

0.72

67.95

68.75

70.35

1.73

.447

BC

97.90

1.00

74.15

0.80

73.80

74.30

75.25

1.42

\(<.005\)

ABC

85.65

0.94

70.15

0.78

69.15

70.20

72.10

3.63

.252

HGBC

99.80

1.00

74.70

0.82

74.30

74.70

76.20

13.49

\(<.005\)

RFC

100.00

1.00

75.00

0.82

74.65

74.95

75.95

5.77

\(<.005\)

GBC

96.95

0.99

69.55

0.81

68.90

69.60

70.75

3.39

.333

MLPC

97.25

1.00

75.25

0.77

75.00

75.30

76.70

28.44

\(<.005\)